But Mourinho disagrees with the system that sees sides drop out of the Champions League - like Ajax did in the play-off round - and join the Europa League along with clubs like United who start off in the tournament.
"I will be picking a team that I think will perform well".
Mourinho stressed that Paul Pogba appears to be a strong and fine guy, possessing a firm mentality. For this reason, we must take them on, but given 10 of their last 15 at Old Trafford have finished all-square we'll keep the draw onside.
Mourinho stressed that the first season at any new club is always hard, but is more optimistic about 2017-18 after what he has learned this term.
"I'm here [in English football] already seven years; I never saw any detail of trying to care about the English teams involved in European competitions".
Asked if he had submitted a request for the game to be moved, Mourinho replied, "I don't lose time".
"I wasn't surprised, I really don't know why you are surprised they reached the final", he said. "We're not going to influence anything one way or the other in terms of results for ourselves, and it would have been a good gesture by the Premier League to have done it to give them the best chance".
The "Special One" will still include a few of his first team regulars in the starting eleven to add some experience to the side but Wayne Rooney is unlikely to be one of them after playing 90 minutes in midweek.
'We will have [Demetri] Mitchell, [Scott] McTominay, Josh Harrop, [Matthew] Willock, [Angel] Gomes, Zachary [Dearnley]. As for Marouane Fellaini, who missed training too, it's still a question.
"So instead of looking at Manchester, I look at my team and the most important thing is we are fit and fresh, nobody is injured and that's a great way to prepare the team for next Wednesday". Southampton boss Claude Puel: "Any teams have a debrief at the end of the season and this is normal but the end of the season is after the last game". These talented players don't arrive at Ajax by accident.
I hope we can enjoy and win both of our games against Southampton and Crystal Palace. "I believe it is not by looking at them, but by looking at ourselves".
"They showed me that they want to be in the final, they want to be an option".