The escapees are wanted for the prison bus murders of two corrections officers: Sgt. Chris Monica and Sgt. Curtis Billue.
Sills said both men were violent repeat offenders and are considered armed and risky.
Any one with information on the case is urged to call the nearest law enforcement agency by dialing 911.
Authorities say the two men overpowered and killed 42-year-old Sgt. Christopher Monica and 58-year-old Sgt. Curtis Billue on a prison transport bus before fleeing in a stolen vehicle. "They have no concern for human life".
The prisoners were part of a group of some 30 inmates being transported by bus by two armed guards.
"If somebody is helping them and we identify who they are, they will be prosecuted as parties to this crime", Sills said.
Authorities put up roadblocks, only to discover Wednesday morning that the pickup had been stolen, about 9 miles (14 kilometers) from the burglary.
Authorities said the last sign of the two fugitives remains the theft of a 2008 white Ford F-250 pickup truck with the Georgia tag BCX-5372 from a rock quarry.
Immediately after the escape, authorities said, the two carjacked a driver and fled in his green Honda Civic and went to Madison, about 25 miles to the north, where they burglarized a house.
Dubose, who was serving a 20-year prison sentence at the time of his escape, likely will not have an easy time hiding in a crowd: His neck is covered with hard-to-miss tattoos, with more ink drawings, in the shape of a crown, engraved over his eyebrows.
Officials said Dubose, almost 20 years his junior, is also a hardened criminal despite his relatively young age, and is a member of the notorious "Ghostface Gangsters" white supremacist group.
The other 31 inmates were left handcuffed inside the transport with the engine running.
The head of Georgia's Department of Correction, Greg Dozier, declined to talk about how the prisoners where capable of overtaking the armed guards.
Ricky Dubose (L) and Donnie Russell Rowe (R) are targets of a manhunt in Georgia, after they escaped an outdoor work detail along Georgia's Highway 16 on Tuesday after two correctional officers were shot and killed. "Sills said investigators were trying to determine how the killers got out of the cage and into the driver's compartment, "USA Today writes". The last thing police know is that the pair stole a vehicle in the early hours of Wednesday morning.
Monica, 42, and Billue, 58, were both transfer sergeants at Baldwin State Prison.
Billue spent 10 years with the Georgia Department of Corrections after rising to the rank of Major in the U.S. Army.
"This callous, heinous crime is another stark reminder how unsafe it is for all our law enforcement brothers and sisters across this country", NYSCOPBA President Michael Powers said in a news release.
Sills also offered new information on what the two inmates did Tuesday after the shooting, which happened around 6:45 a.m.in Hancock County. "Our thoughts and prayers are with the families of the two officers killed and with all law enforcement involved in the pursuit of the escaped felons".
Sills said it appeared the two had driven the auto up a berm of dirt then jumped out at the top and let the Honda careen down the other side and into a tree. Police said they believe it was Rowe and DuBose.