The Blues face four of last term's top six on their return from continental action, with home games against Arsenal, Manchester City and Manchester United as well as a trip to Liverpool coming immediately after Champions League fixtures.
Liverpool host Everton at Anfield in December, while the first Manchester derby of the season sees United and City meet at Old Trafford.
Both the Manchester and Merseyside derbies will take place on the same two weekends this season and the second round of those fixtures could be particularly decisive as the season enters its business end.
Right! Manchester United's league fixtures for next season have been announced and if you see Jose Mourinho's face painted with an uncharacteristic smile, you'll know why.
West Ham start their campaign at Manchester United.
Champions Chelsea will look to start their title defence with a home game against Burnley at Stamford Bridge.
Arsenal, whose manager Arsene Wenger will be firmly in the sights of the disgruntled Gunners fans who didn't wanted him to sign a new contract, face a tricky trip to Chelsea the weekend after.
- Arsenal have won each of their last 10 league home encounters with Leicester City; their joint-longest winning streak at home against a single opponent. In contrast, Manchester City, Leicester and Stoke are away in all three rounds. The end of the season is concluded with an away game against Everton and a home tie with Manchester City in May, one of the most hard ends to the season the Saints could have had. The Hammers do not play at home for the first three rounds of games due to the World Athletics Championships taking place at London Stadium.
The challenge for Burnley is even greater as the champions have not lost on the opening day of the Premier League since going down to Coventry in 1998.
During the 2016/17 campaign, Tottenham hosted Sunderland and Manchester City after European matches and visited Bournemouth, Arsenal, Chelsea and Manchester United.