They didn't hold their tongues, calling Shkreli a "snake", the "most hated man in America" and "the face of corporate greed".
Prosecutors say Shkreli lied to investors at MSMB Capital and MSMB Healthcare about the performance and assets of the investment funds, and that he used money from Retrophin to pay off MSMB investors, as well as his personal loans and other debts.
Brafman had advised Shkreli to keep quiet as he awaited the trial-he was charged and released on $5 million bail in December 2015. That trend continued on Tuesday, with the judge releasing dozens more of the 69 she questioned, including a woman who said she read about Shkreli and thought he "just seems to care about himself".
If convicted, Shkreli could face 20 years behind bars.
"A person who puts profit over everything else".
Shkreli has pleaded not guilty.
Although the charges are unrelated to the controversy surrounding Daraprim, Shkreli says that prosecutors targeted him for both the price hike and his flamboyant personality.
Some jurors didn't pull any punches when saying how they felt about Shkreli.
Last Monday, he sat quietly at his hearing in federal court - and then went home and live-streamed his activities for two and a half hours, The New York Times reports.
Shkreli, a boyish-looking 34, outraged patients and US lawmakers by raising the price of anti-parisitic drug Daraprim to $750 a pill, from $13.50, in 2015, when he was chief executive of Turing Pharmaceuticals.
"I'm excited", he told the AP last week.
The prosecution pursuing charges of securities fraud against "Pharma Bro" Martin Shkreli have been having difficulty finding a jury of Shkreli's peers who don't already have a negative bias against him.
The 34-year-old Shkreli has upended conventional wisdom about avoiding bad pretrial publicity with nonstop boasts and rants on social media. In the months after the initial scandal, he parlayed his viral bit of fame into a troll career of harassing women on Twitter, beefing with various rappers, and livestreaming his entire life on YouTube.
Defense attorneys argue that all of the investors were repaid, and thus Shkreli made reparations to the situation.
In April, he offered $40,000 to a Princeton University student who solved a mathematical proof. "This may be the Government's view, but it's not ours", Brafman said.