All of his "dead" films up to that point had been filmed in Pittsburgh, Penn., which became Romero's adopted home after he moved there for college after being born in NY.
Romero's other films broadened his view of the genre, including Season of the Witch (1973), sometimes marketed as Hungry Wives, which was less of a horror film than it was an exploration of the occult.
In a program shot by the American Film Institute Romero said: "I don't have any supernatural hobgoblins that I worry about". Numerous "rules" of the zombie genre, such as destroying the brain of a zombie in order to stop it, originated from Romero's films.
"His zombie films alone are the work of a major satirist, being highly vivid socio-political metaphors and sometimes better records of the years in which they were made than countless serious dramas".
Although Romero worked nearly exclusively in film, his impact can still be felt in today's television landscape. "George, there will never be another like you", wrote Stephen King.
"Night of the Living Dead" featured black actor Duane Jones in the lead, which was unusual at a time when race relations were testing the country.
Romero will leave a lasting legacy in cinema, and will still continue to influence filmmakers. He graduated in 1960 from the College of Fine Arts in Carnegie Mellon University in Pittsburgh.
Romero was born in the Bronx to Cuban and Lithuanian parents.
The LA Times reported that Romero died listening to the score from "The Quiet Man" and was accompanied by his wife Suzanne and daughter Tina.
Romero started his career shooting industrial films and television commercials with a few friends.