Temba Bavuma, one of three changes in South Africa's top seven in the batting order, made 48 and helped Quinton de Kock (73) put on 119 for the first wicket, while new cap Aiden Markram hit 66 as he and Du Plessis added 151 off 116 balls for the third wicket before Du Plessis retired hurt.
De Kock, wearing a shirt with teammate and opening partner Hashim Amla's name and number on, hit five fours and a six in his half-century and De Villiers hammered eight fours.
Mehidy Hasan and Shakib Al Hasan bowled effectively against a set of rampaging batsmen. Test opener Dean Elgar, recent worldwide debutant Aiden Markram, de Villiers, wicket-keeper batsman Quinton de Kock and limited-overs regular Farhaan Behardien all play at SuperSport Park, while they also have Dale Steyn, Morne Morkel and Chris Morris.
Over the next three overs though, Mehedi and Shakib gave away only 20 runs and that made a difference as de Villiers went for another of his big shots only to hole out to long-off.
Du Plessis, who also won the man of the match for his performance was carried off the field after scoring 91 runs off just 67 deliveries that was the cornerstone of South Africa's total of 369 runs. And though he wasn't too wasn't happy with the decision he didn't even try to review it. They play all over the world in various competitions and they are a team to be respected. They only got five boundaries in that time, but by pinching twos at every opportunity, they were still able to ransack 62 runs.
The SA vs BAN 1st T20I will be telecast live on Sony Six HD (India), Gazi TV (Bangladesh), SuperSport (South Africa), while free live streaming is available on Sony Liv (India).
On the other hand, the home team South Africa will be determined to get the job done perfectly and they will eye to whitewash the visitors in the T20 series as well.