Her husband, Richard Ratcliffe, 42, now says his wife is on the edge of a nervous breakdown.
Tulip Siddiq told Sky News that Nazanin Zaghari-Ratcliffe was "inconsolable", "sobbing down the phone" to her husband and "couldn't believe (Mr Johnson) could make comments that would endanger her life".
Ratcliffe told the BBC he hoped he could travel to Iran with Johnson to meet his wife.
She had previously had been given an inconclusive mammography by the in-prison gynaecologist. The Sunday Times reported that 40 of her own MPs were now calling for her to step down.
Now Environment Secretary Michael Gove has made an "unhelpful" intervention.
She was accused of trying to overthrow the Iranian regime - charges she has always denied - and sentenced to five years' imprisonment. "One of the things I want to stress is that there is no reason why she should be in prison in Iran as far as I know".
The British-Iranian was visiting family in Iran, but is being held on accusations of spying and spreading propaganda. Concern over her physical and mental health is growing, and neither Ms Zaghari-Ratcliffe nor her husband has had access to their daughter, who is being looked after by her grandparents in Iran.
However, Gove said the blame should be on Iran, rather than Johnson.
"Nazanin has been complaining of sharp stabbing pains in her breasts for some months - her breasts have been painful since month 5 of her detention".
The coordinated defence is part of attempts to shore up the government of Prime Minister Theresa May, weakened by a series of scandals and gaffes involving her top team of ministers as she negotiates Britain's departure from the European Union.
She was detained at the airport in Tehran in April 2016 on her way back to the United Kingdom from visiting family with Gabriella, her then 22-month-old daughter.
Richard Ratcliffe said he spoke to Mr Johnson for about 20 minutes yesterday morning, during which the Cabinet minister said he was "deeply sorry for Nazanin's suffering".
In his article, Corbyn says that the "heartbreaking" case of Zaghari-Ratcliffe has left her future liberty in peril because of Johnson's "serial bungling".
"In that case I take exactly her husband's assurance in that regard", he told the Andrew Marr Show.
Labour party leader Jeremy Corbyn called on May to sack Johnson, writing in The Observer newspaper on Sunday that "we've put up with him embarrassing and undermining our country through his incompetence. for long enough".
The wording of Labour's question is not yet known but it is thought, if it is approved by the Speaker, it will be answered by a junior minister in Mr Johnson's department after 2.30pm on Monday.
But in a statement issued yesterday by Mr Ratcliffe, he said it was not in Ms Zaghari-Ratcliffe's interest for any Cabinet members to resign.