The news comes as the production crew wrapped up the filming of the second half of season 7.
If the series is renewed for an eighth season - which the trades say is likely - it will be without Adams and Markle, who play on-screen lawyer couple Mike Ross and Rachel Zane. They were waiting for Gabriel Macht to sign.
Suits fans are not happy with the news and took to Twitter to share their frustration.
In September her co-star Adams tweeted a photo of him kissing Meghan on the cheek but was unprepared for the storm it caused. Ummm, wtf. It won't be the same show without them!
She shut down her lifestyle website The Tig earlier this year and has been spending more and more time in the United Kingdom with other half Prince Harry, fuelling rumours that they'll soon get engaged. A user said, "Huh, not shocked by Meghan Markle. Dunno how it'd work without Mike". Adams had "made up his mind" about leaving.
Both actors' contracts conclude after season seven.
The cast is now filming the second half of the seventh season in Toronto. In fact, according to Deadline, Adams has been looking to move on for some time and, as many of us can guess, although Markle hasn't explicitly stated this, she has plenty of other projects and responsibilities in her life at the moment. She loved being on the show, and we loved having her on the show, that's why we're doing the spinoff. But she is not leaving alone. Even though she left early, look at how often we still see Jessica [Pearson] throughout season 6 and 7.
"I went to bed, and woke up in the morning and realized "Oh, yeah".
Huh, not shocked by Meghan Markle probably leaving Suits due to the Royal Family and all, but Patrick maybe too?