Since the Champions League went from using a second group stage to a 16-team knockout tournament in 2003-04, no league had ever qualified five teams for the knockout rounds - until now.
World Player of the Year Ronaldo has only found the net twice in 10 La Liga games this season, but he broke two more Champions League records in the 3-2 win over Borussia Dortmund.
However, the easy paths each team took to the Round of 16 must be taken into account.
Four teams have transferred to the UEFA Europa League round of 32 after finishing third in their UEFA Champions League groups.
Alan Dzagoev gave the Russians the lead before two second-half goals in three minutes from Romelu Lukaku and Marcus Rashford, who both ended lengthy scoring droughts, ensured the Red Devils progressed as group winners, Basel qualifying as runners-up after beating Benfica.
United join fellow group winners Manchester City, Tottenham, Barcelona, Besiktas, Roma and Paris St-Germain in the next phase. Teams from the same country cannot play each other in the last 16, which limits who Chelsea can play in first knockout stage.
That leaves only Barcelona, Paris Saint-Germain and Besiktas as Chelsea's options.
Chelsea and Atletico Madrid were drawn to a 1-1 score, meaning Chelsea finished second to move onto round 16 while Atletico will continue their European club competition journey in the Europa League.
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Manchester City: Basel (20), Bayern Munich (4), Juventus (5), Seville (7), Porto (12) or Real Madrid (1).
Over the past five years, though, Premier League clubs have found it much more hard to make much headway in the competition.
The draw that will take place on Monday (and that we will cover live here at AS English) starts at 12:00 in Nyon, Switzerland.
Round of 16 first-leg games are played from February 13-21.