Leicester won four of six points from Crystal Palace last season, winning 3-1 at King Power Stadium and drawing 2-2 at Selhurst Park.
The central midfielder serves a one-match ban, and his absence is worsened by respective calf, groin and hamstring injuries to Mamadou Sakho, Joel Ward and Timothy Fosu-Mensah.
If you're not currently a Sky Sports customer but can't stand to miss out on the action, you can add the channels to your box via a NOW TV subscription.
Having not scored an away goal yet this season, Hodgson's side may be viewed as easy pickings for Puel's rampant Leicester side, and given the shambolic nature of Palace's defensive work for the majority of the season, they may be just that come Saturday.
Claude Puel: "It's a good strong team with good structure in their play".
It was Benteke's first goal of the season and his first for Palace since May last term
"We don't see ourselves as a side always being down near the relegation zone and the performances of late have certainly shown that we are capable of being a team at that kind of level and hoping to get in the position in the table that they find themselves in".
"But if you were asking if I'm happy to play two very, very important matches - Man City at home and Southampton away - with one day in between then I can't lie and sit here saying it's perfectly fine because we'll find it very hard. It was a good challenge to see the possibilities and performance of other players but we can not play every game with the same players".
Although their fortunes have improved slightly since the appointment of Roy Hodgson as manager, Palace are languishing in 18th place in the Premier League, while they have mustered just 12 goals in the top flight this season.
Mauricio Pochettino's men appear to be among a host of sides battling it out for second place and you can back them to be the highest placed side in the division aside from Pep Guardiola's men at 12/1 with 888 Sport. The last top-flight team to endure a longer drought on the road were Manchester City, who failed to score in 12 consecutive away league games during the 1949-50 season. However, a worrying festive fixture list, with games against Arsenal and Manchester City before the new year, and their consistently terrible away form remain concerns for Roy Hodgson. Saturday's fixture will feature the longest gap (7,049 days) between a manager facing a particular Premier League opponent.