Antonio Valencia has failed to make the match day squad after sitting out the 2-2 draw at Leicester City.
Sean Dyche's men, who are now in seventh place, have been giving as good as they get against the best of the Premier League and are expected to make life hard for their fancied opponents.
At least United have history on their side in the Boxing Day fixture, having not lost at home to Burnley since September 1962, a sequence of eight wins and five draws.
Eric Bailly is out for the foreseeable future with a serious ankle injury sustained on worldwide duty with Cote d'Ivoire which has resulted in the need for surgery, while Marouane Fellaini could still be unavailable due to a knee injury.
Striker Chris Wood is rated doubtful after picking up a knock against Tottenham, while Stephen Ward, Robbie Brady and James Tarkowski miss out. Former Man United midfielder Robbie Brady will also miss out on a return to Old Trafford, nursing a knee injury.
The France global struggled to impress in his first season back at Old Trafford following an underwhelming return of five goals and four assists last term.
"Two defeats in 2017 in the Premier League so they are not losing five in the second half of the season".
"Adding a suspension does stretch it, but I've great faith in the players". Vokes, with three goals under his belt needs more playing time to prove himself to the manager, and it doesn't come bigger than Old Trafford to show what he is capable of doing at the biggest of stages. "It pops up in our dressing room every now and again as well, we get a bit of The Stone Roses after the game sometimes, I enjoy it". Soccity will only remain ad-free if we receive support from our readers.