Thousands are thought to have taken part in the protests, making them the biggest show of public defiance since 2009, when Iranians - as part of the newly-formed Green Movement - took to the streets to denounce alleged rigged presidential elections by then-President Mahmoud Ahmedinejad.
The latest bloodshed occurred in towns around the central city of Isfahan.
Iranian officials announced 40 rallies across the province of Tehran after Friday prayers, building on huge pro-government marches seen in many other cities over the previous two days.
The death toll stood at 12 on January 1, and before that the Iranian Regime had only confirmed four deaths.
While there's no evidence to suggest Iran used that money directly to fund terrorism, the U.S. State Department lists Iran as a state sponsor of terrorism. He has always been critical of the landmark nuclear deal negotiated in part by the Obama administration, taking steps a year ago to imperil itwithout yet making good on his campaign promise to remove the USA from it entirely.
According to officials, six protestors were killed on Monday night for an attack on a police station in Ghahrijiyan while a total of 15 other protestors have been killed in clashes with police across the rest of the country.
An 11-year-old boy and a 20-year-old man were killed in the town of Khomeinishahr, while a member of Iran's paramilitary Revolutionary Guard was killed in the town of Najafabad.
What began as frustration over Iran's sluggish economy has broadened to include open defiance of Iran's Islamic leadership itself. While the government controls mainstream media, Internet is the biggest challenge for the authorities. Police fired water cannon to disperse demonstrators, images posted to social media showed.
In Tehran, the Iranian capital, 450 protesters have been arrested since demonstrations began.
Leading figures in the Islamic Republic have also been targeted by protesters, including Supreme Leader Ayatollah Khamenei. This brought a strong rebuke from the country's judicial chief.
- with files from the Associated Press. Their 'approach should be strong, ' he said.
Hundreds of people have been arrested and a prominent judge warned on Tuesday that some may face death penalty for their actions. But the anger went deeper than that, and quickly turned into a protest against the Islamic regime in general. Iranians complain that money meant to help ordinary Iranians is being funneled to the IRGC instead.
So far, none of the demonstrations received prior authorisation from the Ministry of the Interior, which makes them illegal in the eyes of Iranian justice.
The EU called on Iran to guarantee its citizens the right to peaceful protest, saying it has been in touch with Iranian authorities and is monitoring the situation. It was, in that sense, an exercise in realpolitik.
Pence repeatedly contrasted the support for Iranian protesters being offered by U.S. President Donald Trump and his administration to the silence at the White House when antigovernment protests broke out in Iran in 2009, early in the presidency of Barack Obama.
People have taken to the streets in cities across Iran to protest against economic hardship and political repression. As for the cause of the protests, Khamenei noted, "I have some things to say about these matters, and I will speak to the people about them". Iranian nationals, after all, are included in Trump's travel ban.