Jack Stephens should continue at the heart of the defence alongside Wesley Hoedt whilst Mario Lemina could come into the team if Pellegrino opts to bulk out his midfield.
Owen has backed Spurs to go on and record a comfortable victory.
Asked if Alderweireld could play against Newport, Pochettino said: "Maybe, maybe".
While Michel Vorm may have to deputise for the France goalkeeper on Sunday, long-term absentee Alderweireld is closing in on a return to first-team action.
The match will be held at St. Mary's Stadium.
The former Madrid manager has previously lauded the Spurs manager for the job he has done in north London, with the Argentinian nurturing an inexperienced team to second in the Premier League past year, four places above Mourinho's United side.
Southampton have cash to spend after sanctioning a big-money move for Virgil van Dijk, though failed in their attempts to lure their former striker Theo Walcott back to St Mary's.
SOUTHAMPTON manager Mauricio Pellegrino has no new injuries or suspensions ahead of the game.
As for Southampton, Mauricio Pellegrino's men have struggled this season in the top-flight with the club winless from their last ten league outings but they did overcome Championship outfit Fulham in the FA Cup Third Round. Therefore, there's mileage in [1.84] quotes on Over 2.5 Goals banking again in Sunday's meeting. With 26 goals, he is easily the most prolific Asian scorer in Premier League history (compatriot Park Ji-sung is his closest challenger with 19) and he became the highest-scoring South Korean in a single European campaign by netting 21 goals in all competitions last season.
Saints go into the match winless in ten league games, and Mauricio Pellegrino's side cannot be expected to turn that run around against a Spurs side who can score at will, evidenced by the rampant 5-2 win last month.