Jahangir received France's highest civilian award in 2014 and Sweden's alternative to the Nobel Prize for her decades of rights work.
She was also the United Nations Rapporteur for Human Rights, and a former Pakistan Human Rights Commission chief.
Known for her outspoken nature and unrelenting pursuit for human rights, Asma, 66, was the first woman to serve as the President of Supreme Court Bar Association of Pakistan.
She was on Time magazine's list of 100 most influential women. "These battles have won her admirers and enemies in great number", a 2013 Firstpost report noted.
She remained Supreme Court Bar President from 2010 to 2012.
"Unfortunately we have lost her", Hina Jilani, also a prominent rights activist, told AFP.
A user tweeted, "Hearing a really bad news about Asma Jahangir Sahiba and praying it isn't true". "It's everyone's loss. What a sad day!"
Asma is survived by two daughters and a son.
Jahangir graduated from Kinnaird College and received an LLB from Punjab University.
The democracy activist was jailed in 1983 for her participation in the Movement for the Restoration of Democracy during the regime of military dictator Ziaul Haque. She was again put under house arrest in November 2007 after the imposition of emergency rule in Pakistan. Her daughter Muneezay Jehangir is a TV anchor.
She has constantly raised the issue of "missing persons" in Pakistan and calling for grilling of intelligence agencies.
Asma was often criticised by the right wingers for her stance towards freedom of speech and against use of religion to curb progressive voices.
Honourable Chief Justice and Honourable Judges praised her services rendered for the cause of independence of the judiciary, rule of law and supremacy of Constitution in the country and said that her services will always be remembered in good words in the judicial history of Pakistan.