The Kremlin had warned Washington that Russian Federation would fend off any strike that jeopardized its servicemen in Syria, and the West respected the red line by giving advance notice of Saturday's attack, just as it did a year ago when it struck a Syrian air base.
A day before a team from the global chemical weapons watchdog was to arrive in Douma, just east of Damascus, Russian Defence Ministry spokesman, Maj.
The strikes - the strongest concerted action yet by Western forces in Syria - were launched at 9 p.m. ET, as most of Europe and the Middle East was shrouded in darkness.
Russia's foreign minister Sergey Lavrov said earlier that Russian experts had inspected the site of the claimed attack and found no trace of chemical weapons. "The attack is the blatant violation of worldwide laws, as well as ignoring the sovereignty and territorial integrity of Syria", Iranian Foreign Ministry spokesman Bahram Qasemi said according to Iranian state media.
She also said that no country should use chemical weapons and go unpunished.
According to a statement by the French presidency, Mr Macron called for dialogue between France and Russian Federation to "continue and intensify" to bring peace and stability to Syria. Putin and Macron instructed their foreign and defence ministers to maintain close contact to "de-escalate the situation", the Kremlin said.
Since 2015 France has carried out air strikes against Islamic State in Syria as part of allied forces linked to the US-led coalition, conducting about 5 percent of total coalition air missions.
A senior French official noted that President Emmanuel Macron did not tell Putin about the strikes when they spoke on the phone Friday, but "certain de-confliction mechanisms" had already been triggered by that point, and "both knew that a new phase was going to begin quickly". "We can not take such risks", he said at a forum.
"The immediate priority is to avert the danger of war", said Ambassador Vassily Nebenzia. "Russia was supposed to guarantee Assad would not use chemical weapons, and Russian Federation did the opposite". The medics, however, said none of the patients had any symptoms of chemical poisoning, according to the statements.
Trump himself appeared on Thursday to cast doubt on at least the timing of any USA -led military action, tweeting: "Never said when an attack on Syria would take place".
Inspectors from the Organisation for the Prohibition of Chemical Weapons are expected to arrive in Syria over the weekend to investigate the reported attack, following an invitation from Damascus.
Russia, an ally of Syrian President Bashar al-Assad, has responded angrily to the strikes, while Syrian state media called them a "flagrant violation of worldwide law".