Seferi, who was almost five stones lighter and seven inches smaller, did show some ambition early on but Fury's height and movement ensured there was never going to be an upset at Manchester Arena.
The start was, however, no less comic, as Fury gave his opponent a tender smooch before the opening bell to Gypsy King's first fight after a lengthy spell of inactivity.
I learned two and a half years is a long time to be out.
Fighting for the first time since he wrested the world heavyweight title from Wladimir Klitschko over two-and-a-half years ago, Fury gurned and showboated his way through much of the contest and earned a ticking-off from referee Phil Edwards. "You can see that he's still got a bit of weight to lose and you can see that he needs the rounds and we'll just have to step up his opponents each time".
Fury (26-0, 19 KO) is next scheduled to fight on August 18 in Belfast against an opponent yet to be named.
This always was going to be an exercise to reintroduce Fury safely back into boxing after the trials and tribulations he has gone through in his two-year, seven-month exile. But Seferi was a nuisance for Fury early, and the former champion was warned for joking around.
Seferi's unsatisfactory withdrawal sent the boos - and the occasional drinks bottle - cascading down from the upper tiers, but for Fury at least, it is simply a case of reigniting a career that still promises much. He's got a good team around him and he's in a good place'.
Fury, who is 28 pounds heavier than when he fought Klitschko, will be encouraged by his performance, but victory should be kept in perspective. Fury then piled on the pounds - he claimed to have lost eight stones in preparation for Seferi - and served a backdated drugs ban for testing positive for a banned steroid in February 2015.
Fury's English rival Anthony Joshua, the WBA-IBF-WBO champion, and American Deontay Wilder, the WBC champion, remain distant targets for Fury, whose priority now will be to build up some momentum against tougher opponents.