The north London club say their first game in their new stadium will be against Liverpool on the weekend of Sept 15-16.
Moreover, any fatigue or injury issues which arise in the Champions League will likely be mitigated by home advantage in their subsequent Premier League fixtures.
Being the unbearably needy dweebs they are, the Premier League have chosen the first day of the World Cup to announce their fixtures for the 2018/19 season.
Some of us won't have got past those first few fixtures...
The first Manchester derby, which will pit last season's top two against each other, is due to take place on November 10 when Jose Mourinho's United make the short jounrey across town.
Manchester United fans have reacted positively to the announcement of the fixtures and believe their side have been handed a boost in their bid to win the Premier League this season with a comfortable looking start and end to the campaign. Pep's team will finish the festive period with a home game on 1 January against Liverpool.
The traditional Premier League 'Clasico' between Liverpool and United is due to be staged at Anfield on December 15, with the return taking place at Old Trafford on February 23.
Elsewhere on the opening weekend, Manchester United host Leicester City, Liverpool entertain West Ham, and Championship winners Wolverhampton Wanderers welcome Everton to Molineux.
On the day that the World Cup begins, attention diverted away from the worldwide tournament for a brief moment, as English football fans start to plan their away trips and look at the clashes with their club rivals after the fixtures were released this morning.