Edmund will also have the backing of a vocal crowd, who are set to have a restless evening, given the Three Lions will face Sweden in the quarter-final of Fifa World Cup 2018.
Djokovic saw chances go begging in the opener, but stepped things up in set two and deservedly levelled after repeatedly putting pressure on the Edmund serve. Djokovic is playing better because grass I think suits his game at the moment, grass usually suits your game better when you're less confident because it's about staying alive in the points.
Edmund can count himself unfortunate to come across Djokovic so early, with the 12-time grand slam victor back on form and playing considerably above his seeding of 12.
Nadal's powerful forehand and his effectiveness on serve - winning more than 80 per cent of the first and second serve put in play during the second set - proved more than de Minaur could handle.
Djokovic is among those who now see Edmund as a major threat to win the biggest titles.
"My game's really improved this year", insisted Edmund, the last British player remaining in the singles draw.
"The country's behind them and I don't think anyone is going to work now". Playing on Centre Court is always like a dream and a great experience. Three years ago, Suarez Navaro had beaten Bencic at Stuttgart in a clay-court duel, but the Swiss player emerged victorious on Wimbledon's grass.
That wasn't the only point of contention in the match. His groundstrokes crackle but more variety is required. "I am really enjoying playing tennis, I just feel free on the court", Hsieh said following the match, which lasted two hours and 20 minutes.
"But today there was just some people, especially behind that end where I got the time violation, they kept on going, they kept on going, provoking".
Meanwhile, Djokovic claimed the partisan atmosphere on Centre Court went too far - defending his decision to blow kisses at the crowd as things got tetchy. That's something that I can tolerate for a little bit.
"If you were in my position, you would probably understand". I just reacted the way I thought it was fair, the way they reacted to me.
"It will help him next time he steps on the centre court anywhere in the world playing the big names".
Edmund acknowledged the rejuvenated form of Djokovic and promised a strong show against the Serb, who will be favourite to progress.
"He does have quality and he has a very good team of people around him", he added. He has a good working ethic. His backhand, we always knew forehand is a weapon, but backhand, he was making a lot of unforced errors from that end.
This was the fourth victory against a Top 10 player for Hsieh, 32, although the former women's doubles world number 1 had never before defeated a current singles world number 1.