Rae revealed a year ago that she had bone and pancreatic cancer, but a cause of death was not immediately revealed. Initially set at a girls' boarding school, that NBC series ran for nine seasons, though Rae left after its seventh year.
According to TMZ, Rae also appeared in "The Love Boat", "101 Dalmatians: The Series", "Sesame Street", "Car 54, Where Are You?".
Mrs. Garrett began on the show "Diff'rent Strokes" (1978-84.) She also briefly reprised the role on the shore-lived "Hello, Larry". Now I have to figure out whether I want to go have treatment again or opt for life, ' she continued.
During her Northwestern years, she performed in the school's annual musical comedy revue known as the Waa-Mu Show and moonlighted on the Chicago-based radio soap opera "Pepper Young's Family".
During her long career, which spanned over six decades, Rae appeared in dozens of movies, TV shows and stage productions - which earned her two Tony Award nominations in 1966 and 1989 for her roles in Pickwick and Morning, Noon and Night respectively.
The Tony and Emmy nominated actress appeared on the popular 1980s sitcom The Facts of Life for almost 10 years, sharing her personal struggles with the writers for the show to keep things realistic.
Born Charlotte Rae Lubotsky in Milwaukee in 2926, she aspired to be a dramatic actress. "I'm grateful for the life I've already had".
"I grew up watching Charlotte Rae teach us the facts of life", wrote one Twitter user. She was replaced by Cloris Leachman.
Charlotte also released a tell-all memoir in 2015 where she detailed her Hollywood experiences including her late husband John Strauss' bi-sexuality.
"Facts of Life" hailed from Norman Lear's Embassy Communications. "No, no, no! If people had a positive experience with Mrs. Garrett, that makes me so happy!"
In addition to Rae's son Larry and his wife, Eleanor, survivors include her sister Miriam, and grandchildren Sean, Carly, and Nora.