Syria is yet to make a statement on whether it was responsible for the disappearance of the Russian aircraft.
Syrian media reported a missile attack on the coastal city of Latakia Monday evening.
However, a United States official with knowledge of the attack, dismissed Russia's claims and told CNN the maritime patrol aircraft was actually inadvertently shot down by the Syrian regime. Some missiles hit parts of the city, according to local media, many of them were reportedly downed by Syrian air defense systems.
Russia's Defense Ministry on Monday said one of its planes carrying 14 people on board "disappeared from the radar during the Israeli attack" after Syria's state media reported that its air defenses had engaged a barrage of rockets fired from the ocean. Earlier this month, an Israeli military official said the Jewish state has struck over 200 Iranian targets in Syria over the past 18 months.
Syrian military sources told SANA that the attack came from the direction of the sea and targeted an Organization for Technological Industries center in Latakia.
Syrian statements have blamed Israel for launching a missile strike. An unidentified military official was quoted as saying Syrian air defences intercepted some missiles heading for the provincial capital of Latakia from the sea.
The plane went off the radar while F-16 fighters of the Israeli Air Force attacked targets in the Syrian province of Latakia, the fate of the Russian military is unknown, the official said. It was unclear if Syrian government or Iranian forces were at the facility.
A second USA official told CNN that the incident occurred during an Israeli attack on sites in Syria.
There has been no comment from the Israeli government about the night's attacks in Syria, which is standard policy regarding military action outside Israel.
Monday's attack came hours after Russian Federation and Turkey announced an agreement that effectively prevents a Syrian government offensive against Idlib, a rebel-held area in northwestern Syria.
Explosions continued for almost a half hour, said state-run Al-Ikhbariya TV, which aired footage showing streaks of white light flashing across the sky.