Debate is guaranteed, particularly after Ronaldo's unannounced absence in Monaco for UEFA's award ceremony - when he discovered that he was not the player of the year.
So, The Best gala is without the two biggest footballers in the world.
Ronaldo is hoping to make it a hat-trick of awards in the Best Men's Player category, having won the title in each of the two previous years, and this time round finds himself up against former Real Madrid teammate Luka Modric and Liverpool striker Mohamed Salah.
A list of 15 nominees will be selected by France Football and a panel of global journalists will vote on a victor.
Messi has not made the shortlist for the first time since 2007 and Modric was the player of the tournament at this summer's World Cup and won UEFA's player of the year last month.
Join Gary Neville and Kelly Cates for a star-studded night at the Royal Festival Hall - tap or click the video above from 7pm to watch the preview show, with the ceremony due to start from 7.30pm.
Messi's strike faces competition from Gareth Bale's overhead kick in the Champions League final, while Ronaldo's acrobatic effort against Juve in the quarter-finals and Salah's goal in Liverpool's 1-1 draw with Everton in December 2017 are also among the 10 candidates.
Modric is arguably in pole position for the main award after winning the Golden Ball at this summer's World Cup in Russian Federation where Croatia finished runners-up.
Meanwhile, the Best Women's Player Award is between Ada Hegerberg of Norway and Lyon, Dzsenifer Marozsan of Germany and Lyon, and Marta of Brazil and Orlando Pride.
Ronaldo and Messi, though, will not be alone on a panel of illustrious talents. The gala event, which is now in its third year, is to be hosted by actor Idris Elba and journalist Anne Laure Bonnet, with the following shiny gongs to be handed out: Best Men's Player, Best Goalkeeper, Best Men's Coach, Best Women's Player, Best Women's Coach, the Fifa Puskas Award, the Fifa Fan Award and the Fifa Fair Play Award.