The 43-year-old former England global has been a stern critic of Mourinho and did not hold back ahead of United's clash with Valencia on Tuesday night.
This was the fourth straight match in all competitions that the Portuguese's side had failed to win, meaning scrutiny will only intensify ahead of Saturday's Premier League visit of Newcastle.
The harsh reality is that Mourinho's team is playing poorly and failing to win matches, which is a risky combination for any manager.
Indeed, Rashford was responsible for all of United's best first-half moments, also drawing a routine stop from Neto and seeing a header blocked by Ezequiel Garay. For some, the last straw in Jose Mourinho's reign.
Mourinho questioned how much some of his players cared about United's poor form on the eve of the match, while his program notes suggested his group lost their dignity at West Ham.
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He said: "I am pleased with the effort, I am pleased with the commitment, I am pleased with the improvement". "Uefa were nice, the referee was nice to allow us to start the game five minutes later because we at least needed half hour to be prepared but it was not a problem with the club organisation".
Minor details are important. His team selection and set up was freaky considering the improved performances in the last two away games.
Arriving late meant that the prematch preparations were disrupted, and regardless of the result, that should not happen at a club of United's stature.
The setback was the last thing under pressure boss Jose Mourinho needed as he hopes to end a winless run across three games following a draw at home to Wolves a shock League Cup exit by Derby County and a crushing loss at West Ham on Saturday.
That said, there we some positives on the pitch in a dismal game, with both Luke Shaw and Marcus Rashford showing that they now deserve to be trusted by Mourinho. But which players should take most of the stick?