A limousine "failed to stop" at an intersection in upstate NY and struck a parked vehicle, leaving 20 people dead, State Police said Sunday.
Mr Cuomo also told a news conference that the driver did not have the appropriate licence for it.
On Sunday, Cuomo released a statement saying, "My heart breaks for the 20 people who lost their lives in this horrific accident on Saturday in Schoharie".
"We'll determine whether there is any criminal culpability on the part of anyone, and if there is, we will hold them accountable", Patenaude said.
Mr Cuomo told reporters the vehicle failed a state vehicle inspection last month and the driver did not have the correct permit to operate a limo with passengers. The board is now examining when and how the vehicle was converted and what caused this tragedy.
Prestige Limousine, the vehicle's operator, was ordered to cease operations until the investigation is complete. Officials worked with the state to stop heavy trucks using the intersection, she said, but accidents had continued to happen. James Seward, R-Milford, said the legislators hope to see improvements, though they will wait until the state police and NTSB conclude their investigations.
The crash killed 18 people inside the limousine, including the driver, and two bystanders.
Before the limousine crashed, on the way to a birthday party, one of the victims, Erin McGowan, texted a friend that the limousine was in bad condition and appeared to have motor trouble, the New York Times reported.
The fatal accident came just 20 minutes after one of the occupants texted her cousin, saying the limo was "in awful condition".
"They did the responsible thing getting a limo so they wouldn't have to drive anywhere", she said, telling the paper that several of the couples had young children.
"They were handsome girls, full of life".
The women's aunt, Barbara Douglas, told the New York Post they were "beautiful girls".
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Autopsies were being performed on the dead but authorities didn't say whether the limo occupants were wearing seat belts, nor did they give any indication as to the speed of the vehicle.
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"I'm not an engineer, but I can tell you, coming down that hill even in regular auto or my pickup truck, you have to pump your brakes", said state Assemblyman Christopher Tague, R-Schoharie.
Like the McGowans, Steenberg and her husband, Axel Steenberg, had just gotten married in June; Axel's brother, Rich Steenberg, was also killed in the limousine crash, she said.
Douglas said three of the sisters were with their husbands.
Patrick Cushing, and his girlfriend of two years, Amanda Halse, have also been confirmed as among the dead.
"We don't know the cause of the accident, if it was a vehicle malfunction, if it was a driver malfunction (or) a driver error", Cuomo said.
"We've had three tractor-trailer type vehicles - they come down that hill too fast, they go through our parking lot and they end up in a field behind our business", Kirby said. "It's a terrible tragedy and there's no words to describe how we feel".
"That company and that vehicle have been under scrutiny at the DOT (Department of Transportation) in the past", said state police Major Robert Patnaude. A longtime resident of the inn said that for at least two years Hussain kept limos on the property and seemed to care little about safety.
In inspections September 4, the company's limos were cited for defective brakes, lack of proper emergency exits, flat or balding tires, defective windshield wipers, and other maintenance problems.