Van Dijk has been one of the biggest influences in Liverpool's new found belief, the Reds not conceding a league goal at Anfield since February, and recording more clean sheets than any other English club in that period.
Any prolonged lay-off however would be a major blow for Liverpool as they look to keep up their flying start to the season and repeat their European heroics.
The game was a far cry from the four explosive encounters last season which brought 18 goals, but Mahrez praised City's defensive performance.
Andy Robertson has faith Liverpool can maintain a Premier League challenge this season - but dismissed any suggestion of there being a battle exclusively with Manchester City. We have played City often and they are outstanding. The Guinean midfielder stayed overnight in a Naples hospital after suffering a back spasm.
"I look at Liverpool's midfield and I bet they are three great lads, who work their socks off but they just haven't got that little bit of quality in games like this to look one way and deliver a pass the other way".
James Milner's hamstring injury changed the complexion of the game as City took advantage of Naby Keita's arrival to exert their influence in opposition territory, although again without any real danger for their hosts. In the league, City has clicked into gear and are already top of the Premier League table only dropping points away to Wolves at the end of August.
The result of today's game could provide an early indicator of whom will win the title this season and the Reds are more likely to claim three points on Sunday after not losing a home game to City in the Premier League since May 2003.
Raheem Sterling will be relishing his return to Anfield, and the England attacker is likely to be handed a starting role on Sunday evening.
"If somebody would have told me after eight matchdays you have 20 points, I would say with that fixture list: 'I'll buy it, let's start with the ninth matchday, '" Klopp said.
"There was nothing really in the game - it was two really good teams going at it". Benjamin Mendy is also fit for the game, and the return of the French worldwide is another positive for Pep to ponder in his team selection. At this moment, there 3 joint top leaders of the Premier League.