Ampadu took up the coaching role at Arsenal in 2012 after making three first-team appearances for the club as a player between 1988 and 1991.
The Arsenal legend has minimal coaching experience in English football, aside from a brief spell of work within the Gunners' youth ranks, and taking on such a job of unenviable difficulty would simply not have been the correct fit for the Premier League icon.
Monaco are having a tough start to the season.
But the 41-year-old has made a decision to return to the club he first played at as a professional.
Thierry Henry has now returned to the club where he started his career in 1993 before leaving in 1999 after 141 games scoring 28 goals.
Henry had worked alongside former Everton boss Roberto Martinez in the Belgium set-up, and helped the side to a third-placed finish at the World Cup in Russian Federation. He scored at least 20 league goals in six consecutive seasons and became Arsenal's all-time leading goalscorer.
The former Arsenal striker has a strong link with the principality side.
Henry became the latest member of the France squad that won the 1998 World Cup to fully embrace a coaching career, following Laurent Blanc, Didier Deschamps, Patrick Vieira, and Zinedine Zidane among others.
"I have had an incredible two years helping Roberto Martinez coach this wonderfully talented group of players and watch them blossom into the great side they are today". He can count on our trust and all our support to bring a new dynamic to the team and carry out its mission'.
"His knowledge of football, his passion for the game, his high standards and his commitment to our colours make his nomination a reality".