In the south, flames leapt and raged from Thousand Oaks south through the northwestern San Fernando Valley of Los Angeles and appeared headed inexorably towards the Pacific Ocean.
Fire officials issued evacuation notices for homes on the east side of Chico, a city of about 93,000 people situated about 145 kilometres north of Sacramento.
In the South, residents were forced to flee the beach community of Malibu in the face of a major firestorm fanned by winds gusting up to 80km per hour.
A Chico County police officer called in to "Shepard Smith Reporting" Friday to describe the devastation a deadly, fast-moving wildfire has caused in the town of Paradise, California. The official estimate of acreage burned is nearly certainly on the low end, as the fire is spreading at an astonishing 0.32km² per minute.
Meanwhile firefighters operating bulldozers have been authorised to push cars off the road to clear a path and try to beat back the flames.
"It's a very unsafe and very serious situation", Butte County Sheriff Kory Honea told the paper.
The Woolsey Fire has already scorched 8,000 acres and is at zero percent containment as of Friday, fire officials told Accuweather.
Yesterday, the Northern California city of Paradise, a retirement community of 27,000 located in the Sierra Nevada foothills, and home to two Assemblies of God churches, was evacuated due to the approaching Camp Fire.
The California Department of Forestry and Fire protection - known as CAL Fire - said: "Firefighters continue to be challenged with extreme fire and weather conditions including strong winds and with long range spotting".
An estimated 75,000 homes were also evacuated along the borders of Ventura and Los Angeles counties, according to AP.
With the Camp Fire still raging, Butte County school officials have chose to close all public schools until at least after the Thanksgiving break.
Actress Alyssa Milano, one of Kardashian's neighbours in Calabasas, wrote on Twitter that she was also evacuated. She and her husband grabbed their dog, jumped in their pickup truck and drove through flames before getting to safety, she said.
Accidents gridlocked routes out of the town and residents abandoned their cars and fled on foot carrying children and pets, Reuters quoted local officials as saying.
Numerous people reported missing on social media are elderly.
The wind-driven blaze also spread to the west and reached the edge of Chico, a city of 90,000 people.
In Los Angeles, another, smaller fire in Griffith Park forced the Los Angeles Zoo to evacuate a number of show birds and some small primates on Friday as flames came within less than 2 miles (3 km) of the facility, zoo officials said in a statement.
Using data from various government sources, spatial analytics company Esri has created two interactive maps to help people track the progression of the fires and stay up to date on traffic and smoke forecasts.
The region has grappled with serious wildfires in recent years, including the worst in the state's history - the Mendocino fire in 2018. The message I want to get out is: "If you can evacuate, you need to evacuate", he said.