The claim that the USA is seeking to mount pressure on the Iranian government and not on the people is totally wrong, he said, adding, "With their inappropriate and wrong sanctions and by targeting (Iran's) banking system and oil exports..."
Rouhani stressed that the Iranian people and government are united against the USA pressures and resist them.
"These sanctions will hit the Iranian oil sector, banks, and shipping, and will make it hard to do business with them".
Dr Lina Khatib, head of the Middle East and North Africa program at the Royal Institute of International Affairs, said: "Iran is already under financial strain due to both its adventurism in Syria and the USA withdrawal from the nuclear deal, which reduced the Western private sector's interest in Iran".
The US had announced plans to drive Iran's oil exports down to zero, but backed off from its policy and granted waivers to at least 8 countries that import Iranian oil.
The United States seeks to force all the importers of Iranian oil to eventually reduce their imports to zero.
"It's with some satisfaction that I noticed today the price of oil is down". They cover 50 Iranian banks and subsidiaries and more than 200 persons and vessels in its shipping sector as well as targeting Tehran's national airline, Iran Air, and more than 65 of its aircraft.
Washington vowed to be "relentless" in countering Iran, with Secretary of State Mike Pompeo saying the U.S. wanted Iran to make a "180-degree turn" and abandon its "current revolutionary course". "Once again, the USA has imposed sanctions against Iran..."
Tension between Washington and Tehran mounted since May, when Trump unilaterally withdrew his country from the 2015 landmark nuclear deal signed between Iran and the P5+1 group of nations - the five permanent UN Security Council members: the U.S., Russia, China, Britain, and France, plus Germany.
When Trump came into power he denounced the agreement as one of the worst ever done by United States as it gave Iran too many benefits in return for too little restrictions.