Scotland have beaten Six Nations champions Ireland, England, France, Wales and Australia at Murrayfield in the last two years, with a narrow 22-17 defeat by New Zealand 12 months ago their only defeat in their 11 previous tests at home.
Television footage appeared to show Kolisi's head making contact with the head of Peter Horne as he tried to extricate himself from being pinned to the floor by the Scotland centre towards the end of a pulsating Edinburgh encounter.
Scotland then levelled the scores again with a brilliantly worked move from the training ground - Stuart McInally feigning a long throw at the lineout and Hamish Watson taking it short to score.
However, South Africa's win is likely to come at a cost after an incident involving Kolisi and Scottish back Horne while the pair were on the floor at a ruck in the 30th minute.
The Springboks go to Wales next weekend, and Scotland hosts Argentina.
That prompted South Africa's next penalty attempt to be taken by replacement Elton Jantjies.
"I think South Africa have gone back to their traditional rugby".
The Springboks remain buoyed by their win over New Zealand in September and represent the biggest test Scotland have faced at Murrayfield since they were beaten by the All Blacks past year. We just needed to execute. "We could have scored another try in the first half but they counter-attacked well and we made errors". "We are disappointed, but we need to look at ourselves and make sure we generate quick ball". Rassie Erasmus has certainly had a very positive approach on them and we're now seeing what we always expect from South Africa, a very physical side with good strategy behind them.
Wales have won the last three matches between the sides since the Boks dramatically beat them in the quarterfinals at Rugby World Cup 2015. 'This is the last game of the season for a lot of the guys, so one more week of hard work and they can have some time off. "They're one of the best teams in the world and certainly we've got a massive challenge this week, one we're very excited about but it will be great to see where we are at going into such a big year, it's great that we get to play these teams and playing them at home is even better". 'It's your job and when you play for South Africa, you're representing your country.
Jones sliced through the Springboks' defence and cleverly offloaded to Maitland, before racing on to the ball again and providing the killer pass to Horne to dot down.
It was Scotland's turn to apply some pressure but the decision to turn down the posts after 63 minutes and instead kick to the corner was one they would later regret, while Russell was fractionally off target with an ambitious long-range drop-goal attempt.
And Scotland will continue to play a wide game, he stressed.