The Soyuz MS-11 carried Russian cosmonaut Oleg Kononenko, Canadian David Saint-Jacques and NASA's Anne McClain from Earth to dock with the ISS later on Monday. You can see more awesome launch photos in our full gallery. It is the first mission since an aborted launch in October.
NASA said, the launch comes less than two months after a booster failure forced a Soyuz spacecraft carrying Russian cosmonaut Alexey Ovchinin and USA astronaut Nick Hague to make an emergency landing.
But today, everything went precisely according to plan, with an on-schedule and anomaly-free liftoff at 6:31 a.m. EST (1131 GMT). The spacecraft made four orbits over six hours as it chased down the space station for the docking.
"Risk is part of our profession", the 54-year-old said at a press conference.
The launch will be a test for Russia's space industry, which has suffered several high-profile crashes in recent years but remains the only reliable way to deliver crew members to the orbiting station.
NASA administrator Jim Bridenstine meanwhile thanked the USA and Russian teams "for their dedication to making this launch a success".
"We are psychologically and technically prepared for blast-off and any situation which, God forbid, may occur on board".
Reports say a Russian Orthodox priest blessed their rocket before its flight on Monday, as per tradition.
Kononenko, McClain and Saint-Jacques smiled and gave thumbs up to the cheering crowd including relatives as they ascended into the Soyuz capsule on Monday morning.
One is NASA's very own Ann McClain, along with the Canadian space agency's David Saint-Jacques and Oleg Kononenko of Russia's Roscomos.
The accident highlighted the "smart design of the Soyuz and the incredible work that the search and rescue people here on the ground are ready to do every launch", he said.
NASA astronaut Anne McClain, David Saint-Jacques of the Canadian Space Agency and Oleg Kononenko of Russian space agency Roscosmos docked with the station at 11:33 p.m. (1723 GMT; 12:33 p.m. EST) Monday.
European Space Agency astronaut Alexander Gerst, NASA's Serena Aunon-Chancellor and Sergei Prokopyev of Roscosmos were set to greet the trio on arrival at the ISS.
A Russian investigation attributed the failure to a sensor that was damaged during the rocket's final assembly.