The healthy baby girl was delivered last December to a 32-year-old woman who wasn't born with a uterus.
Besides saving the life of patients with failed vital organs, scientists have also conducted hand or face transplants in recent years to improve a person's quality of life.
A womb transplant is performed by removing the womb from the donor and transplanting it into the recipient by connecting the two major veins and a series of arteries, ligaments and vaginal canals, according to The Lancet.
Five months after the transplant, the uterus showed no signs of rejection and the recipient was menstruating regularly.
"Successful pregnancy, without evidence of any compromise in spite of the uterus (womb) being without oxygen for eight hours before transplant, was unique". "While uterine transplantation sounds extreme, it can be indicated in women born without a uterus, or in women who have a non-functional or surgically-absent uterus".
She added that the outcomes and effects of womb donations from live and deceased donors have yet to be compared.
The Journal cites 10 previous cases of failed uterus transplants from deceased donors, in the USA, the Czech Republic and Turkey.
Doctors said in the study that the woman felt "fulfilled" by the chance to carry and deliver her own daughter in spite of her condition. In this case, a cesarean section was performed for birth at 35 weeks gestation, and along with the delivery of an nearly 6 pound healthy baby girl, the uterus was also removed.
Women who have irreversible infertility are the primary candidates to receive a transplant.
Dr Wellington Andraus of the department of Gastroenterology at the University of Sao Paulo who also worked on the case study told Newsweek the woman's story is a "source of hope" for patients struggling with fertility caused by the uterus or a lack thereof. The live donors need to be family members of the woman and be willing to donate, as per the current practice. This affects approximately 3 to 5 per cent of women, Dr. Tullius said, including those born without a uterus or those who have had hysterectomies for cancer-related reasons. Of this group, around one in 500 women have uterine problems. Immunosuppression was continued outside of hospital until the birth.
In 2011 a team in Turkey was the first to transplant a uterus from a deceased donor, but the procedure did not lead to a live birth. Seven months after the transplant, doctors transferred an embryo made via in-vitro fertilization from the woman's egg and her husband's sperm into her womb.
There have been a total of 39 live donor transplants, resulting in 11 live births in the past five years.
Experts say that path breaking procedure will broaden the access to many of whom who would otherwise be left with an option of adoption or surrogacy to have a child. "The numbers of people willing to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population". In the first, the uterus had to be removed from the recipient after an infection occurred; Flyckt said she couldn't say where things stood with the second case other than that the recipient was doing well.