If travel is necessary please refer to MoDot's interactive road map here: Missouri DOT Road Conditions.
So far Missouri has had the worst of the snow, with more than a foot (30cm) on Saturday morning around St Louis and Jefferson City.
The University of Missouri men's basketball game Saturday at the University of SC was moved to Sunday because of weather-related travel problems, the team tweeted.
Missouri isn't the only state being hit by this traveling snow storm.
Winter storm warnings stretch from areas in Kansas to Rhode Island as Gia continues to drop snow across hundreds of miles.
About eight inches of snow had fallen there by early afternoon.
The storm will gear up across central Colorado, then move east across the Plains. Heavy snow and freezing rain began on Friday across Missouri and Kansas.
The system was spreading into the Mid-Atlantic region Saturday afternoon. It would be the most snow the city has had in a single storm since 2014 when a January blizzard dumped 10.8 inches.
At St. Louis Lambert International Airport, "a winter storm has forced dozens of cancellations across all airlines at STL". In St. Louis on Friday night, parts of I-44, I-55, I-64 and I-70 were partially closed because of current snowfall, and more is on the way.
Half a foot of snow also is expected to fall across southern Illinois, Indiana and into Virginia.
Snow will reach the mid-Atlantic by late Saturday through Sunday, but snow totals will be lower there.
The storm is expected to drop 8 to 12 inches of snow in the St. Louis metropolitan area into eastern IL between Friday and early Sunday.
And in IN snow accumulations of 5 to 7 inches are expected between midnight Friday and 7 a.m. Sunday in portions of central, south central, southeastern, southwestern and west central Indiana.
The Appalachians will pick up some snow and sleet in Virginia, down through North Carolina and Tennessee.
Bands of icy rain are forecast for areas farther south, including parts of Virginia and SC. Lower accumulations are expected in DE and Baltimore, as well as around Richmond, where precipitation Sunday should be freezing rain.
"There's snow time like Showtime", the Chiefs said on Twitter, sharing video of the team's quarterback Patrick Mahomes arriving at the stadium in the snow.
The Southeast has seen abundant precipitation in December and January, and the additional rain could put a strain on rivers already high.