Hopefully he'll heal fast and we'll have him back ASAP.
Itoje will remain at the squad's Surrey training base to continue his rehabilitation and in the meantime England must decide how to cover for the loss of a player who coach Eddie Jones believes will soon be recognised as the best lock in the world.
"We will be better in the next game because we are still growing", he said.
"One of my frustrations is we haven't tended to start competitive campaigns overly well".
A long line-out from Jamie George sent Manu Tuilagi barrelling into the green line, giving England fans a glimpse of what they've been missing in the six years since the centre last started in the tournament. We'll go through it and find out why that was.
Taking all of that into account and the fact they have England to come at what is bound to be a bearpit of an atmosphere in Cardiff, backing Wales at [4.1] to win the Six Nations championship doesn't look to be a bad bet. I didn't see Daly out there, I thought it was May.
"There are a lot of guys hurting at the moment and they will be looking for a way back in and I think the only was back in is to roll our sleeves up, show that resilience mentally that we are going to be have to be able demonstrate next Saturday".
"He's in your face, he's someone teams do not want to play against".
"I was on daddy daycare, so it was 'there you go!' Straight back down to earth - changing nappies and doing school runs", he said.
"They put in some really good hits and they seemed a bit more pumped than we were".
With Italy away to come next the game with England in Cardiff is not surprisingly the hottest ticket in town right now and Wales shouldn't be underestimated as they look to upset the odds and topple a much fancied England side. England may have missed 28 tackles to Ireland's 13, but the ones they did make they conclusively won: they registered 48 dominant tackles - those which stop the opponent getting over the gain-line - to Ireland's eight.
Here on SunSport we'll be running a LIVE BLOG from Dublin which will keep you up to date with all the drama.