The pop star, who won best pop vocal album for "Sweetener" earlier in the evening, also liked a few tweets that signified her true feelings about the award.
Grande and Miller dated for two years before he died of an accidental overdose in September.
The rapper and pop star's loyal fandoms are well aware of the mutual adoration they share for each other, which made headlines past year when it was revealed that Cardi performed to "Bad Romance" (backstage dancers, signature dance moves and all) during her high school talent show. "NO." she said in another deleted response to a fan.
Despite being nominated, Ariana was not attending the event herself after she reportedly fell out with producers over which songs she could perform on the night, according to The Daily Mail.
Leading the celebrations, Lil Kim wrote, "Thank U Jesus!"
She added: "I know I'm not there tonight".
But nothing could compare to the raw emotion she showed in her acceptance speech.
In a not so typical speech, she joked her nerves were so bad "maybe I need to start smoking w**d".
Shortly after Cardi accepted the award, Grande hopped on Twitter to call the decision "literal bullshit" and "trash".
Wearing her dark locks straight down onto her bare shoulders, she took to the stage with husband, rapper Offset.
Offset's debut album will come two months after The New York Times reported it would be released: on the rapper's 27th birthday, December 14.