Eddie Jones has targeted victory over the "greatest Welsh side ever" as he seeks to avenge critical comments made by Warren Gatland previous year.
Wales head coach Warren Gatland made 10 changes for the Stadio Olimpico encounter, handing Six Nations debuts to Leicester wing Jonah Holmes and Wasps flanker Thomas Young, while scrum-half Aled Davies and back-row forward Aaron Wainwright made first Six Nations starts.
"All I know is that we are playing against the greatest Welsh side ever", he said.
'A lot of people will write us off, which is a good position to be in, ' Gatland said.
"It's awesome to play for England at the moment but I am not the type of guy to get ahead of myself and neither are the team".
Such a performance in the opening period wrapped up a bonus-point by the break, with further scores coming in the second half through Cleall, Hannah Botterman and Catherine O'Donnell.
England were keen to build on the brilliant opening victory over holders Ireland in Dublin and they did just that with another dominant display at Twickenham. "You've got to earn every point against them".
"Our focus and discipline to keep France scoreless was outstanding". He would have been listed as a try scorer had he not been unceremoniously brought to ground without the ball by Gael Fickou with Ashton favourite to win the chase and touch down in the second-half - a penalty try being awarded and the Frenchman sin-binned. "We had a quick chat after the game and we felt we left 15 or 20 points on the field today so there is a lot more in this team".
England were not done before half-time, when McKenna's superb line break set up Breach for her second as she dived over in the corner as the bonus-point was secured before the break.
"At the moment we are having a great deal of success with our kicking and if you chase well it's hard to counter". The teams meet again in Yokohama in October. "To score a try for your country is awesome and especially at Twickenham so I am very grateful and very lucky", he said.
And, he's also learned that he needs to be less autocratic with John Mitchell appointed in September and Scott Wisemantel, who came in on a temporary basis in the summer, given the job on a more permanent basis recently too.
England's kicks in behind put Huget under heavy pressure in the first half before he was removed for failing a head injury assessment at half-time, while the hosts constantly found space in behind Damian Penaud on the wing, although the 22-year-old was in fact one of their better players.