Two English sides met in last season's Champions League, of course, when Liverpool eliminated Manchester City in the quarter-final stage.
In recent years, Spain has dominated the tournament but Real's three-year reign is over and Barca are the only Spanish side left though no-one will want to play Messi and co.
The last time the two teams faced each other was in the 2011 UEFA Supercup, when Barcelona won 2-0.
Top of Group F and produced commanding victory over Schalke in the Round of 16, winning the second leg 7-0 for 10-2 on aggregate.
The Champions League quarter-finals draw will take place on Friday, March 15 at UEFA headquarters in Nyon, Switzerland.
Liverpool joined Manchester City, Manchester United and Tottenham in the last eight of the competition by beating Bayern Munich 3-1 in Germany on Wednesday.
"You can't tell your players to not try in the Champions League because we want to put all our eggs in the Premier League basket, its hard enough to win any tournament, especially when Manchester City are around".
'They are doing so, so well during the competition that I think it would be unbelievable for one of them.
Manchester United round off the quartet of English teams still in the competition, but Ole Gunnar Solskjaer's side needed a helping hand - both from Presnel Kimpembe and the Video Assistant Referee - to complete a stunning comeback against Paris Saint-Germain.
"They are playing brilliantly and the results have been incredible". They have undoubtedly got the quality and the confidence at the moment.