Starting in September, "A Little Late With Lilly Singh" will be in the 1:35 a.m. nightly time slot.
Singh's YouTube channel, in which she creates comedic and other videos, has more than 14 million subscribers, NBC said. When A Little Late hits the small screen, Singh will be the only woman host of a talk show on any of the major four networks.
"A huge shoutout to all the women who have been before me and are now in the space because I couldn't have done it without them paving the path", Singh says in her announcement video on Jimmy Fallon's show.
NBC has found its new late-night star.
"I'm so excited because I truly get to create a show from scratch".
Singh is slated to take over as host of what was previously "Last Call With Carson Daly", after Daly, who hosted the show for 17 years stepped down last month. "Now that is a dream come true", she said in a statement.
Executive vice president, special programs and late night at NBC Entertainment, Doug Vaughan said Singh is "a star" and they are "thrilled to welcome her to [the] NBC family". "I'm thrilled to bring it to life on NBC, and I hope m parents consider this to be as exciting as a grandchild".
Now the 30-year old comedian, who is also known as Superwoman, is set to join the late night arena with her very own show on NBC: A Little Late With Lilly Singh.
Singh made her YouTube debut in 2010, posting comedic and inspirational. "This has been SO long in the making and I'm so happy I can finally share this with you".
In the February 24 tweet Singh referred to herself as "female, coloured, bisexual", adding: "Throughout my life these have proven to be obstacles from time to time".
She has since branched out into music, writing and acting, with small roles in Ice Age: Collision Course and HBO's Fahrenheit 451.